Patch amphotericin

AB - We present experimental procedures describing the creation of perforated patches by use of amphotericin B. Overview Fingerprint. Abstract We present experimental procedures describing the creation of perforated patches by use of amphotericin B. Access to Document Link to publication in Scopus. Link to the citations in Scopus.

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AmB was pulverised with poly vinyl alcohol and poly vinyl pyrrolidone to form micronised particles-loaded gels, which were then cast into DMP moulds to form the tips.

This is an easy way to fabricate and load microparticles into DMP, as few steps are required, and no organic solvents are needed.

AmB had no covalent chemical interaction with the excipients, but the crystallinity of AmB was reduced in the tips.

AmB was completely released from the tips within 4 days in vitro. AmB DMP were able to pierce excised neonatal porcine skin at an insertion depth of Ex vivo dermatokinetic and drug deposition studies showed that AmB was mainly deposited in the dermis. AmB remained at high levels Pharmacokinetic and biodistribution studies showed that AmB concentration in plasma, kidney, liver, and spleen in the AmB DMP group was significantly lower than that in the IV group.

Accordingly, this system addressed the systemic side effects of intravenous injection of AmB and localised the drug inside the skin for a week.